LYMPHOID NEOPLASIA Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1
نویسندگان
چکیده
1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON; 2Institut Biologie Structurale Jean-Pierre Ebel, Centre National de la Recherche Scientifique, Grenoble, France; 3Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, Toronto, ON; 4Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, ON; and 5Protein Function Discovery Group, Queen’s University, Kingston, ON
منابع مشابه
Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.
E-proteins are critical transcription factors in B-cell lymphopoiesis. E2A, 1 of 3 E-protein-encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein. An interaction involving a region within the N-terminal transcriptional activation domain of E2A-PBX1, terme...
متن کاملE2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.
The E2A gene encodes DNA-binding transcription factors, called E12 and E47, involved in cell specification and maturation. E2A is also involved in a chromosomal translocation that leads to the expression of an oncogenic transcription factor called E2A-PBX1 in cases of acute leukemia. In the work described here, we elucidate the interaction between E2A-PBX1 and transcriptional co-activators. We ...
متن کاملFunctional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300
The E-protein transcription factors play essential roles in lymphopoiesis, with E12 and E47 (hereafter called E2A) being particularly important in B cell specification and maturation. The E2A gene is also involved in a chromosomal translocation that results in the leukemogenic oncoprotein E2A-PBX1. The two activation domains of E2A, AD1 and AD2, display redundant, independent, and cooperative f...
متن کاملBmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Loss-of-function alterations of INK4A are commonly observed in lymphoid malignancies, but are consistently absent in pre-B cell leukemias induced by the chimeric oncoprotein E2a-Pbx1 created by t(1;19) chromosomal translocations. We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the ...
متن کاملRetrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors
The oncogenic transcription factor E2A-PBX1 is expressed consequent to chromosomal translocation 1;19 and is an important oncogenic driver in cases of pre-B-cell acute lymphoblastic leukemia (ALL). Elucidating the mechanism by which E2A-PBX1 induces lymphoid leukemia would be expedited by the availability of a tractable experimental model in which enforced expression of E2A-PBX1 in hematopoieti...
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تاریخ انتشار 2012